Ascorbic acid deficiency, adrenal cortex

Ascorbic acid depleted in adrenal cortex on stimulation by ACTH Biotin and vitamin A adrenocortical insufficiency noted in biotin and vitamin A deficiency... 

Ascorbic acid may be required for steroid hormone biosynthesis depleted from adrenal cortex on cortical secretion Biotin adrenocortical insufficiency noted in biotin deficiency... 

There are suggestions in the literature that, in addition to ascorbic acid, pteroylglutamic acid, the antipernicious anemia factors, and the adrenal cortex may play a role in tyrosine oxidation in the animal body. The evidence for this is that liver homogenates from rats deficient in pteroylglutamic acid were unable to oxidize tyrosine at a... 

The adrenal cortex is very rich in steroids and in ascorbic acid, and is either a factory or a storage depot for these reactants. The metabolic disturbances due to cortical deficiency may be associated with lack of ascorbic acid, and there is evidence that this vitamin is of therapeutic value in the treatment of Addison s disease (Sclare, 1937). The sexual disturbances associated with cortical dysfunction in the female originate probably from abnormal sterol metabolism, as a result of which the tissue either produces an androgen or fails to destroy one. 

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