Ascorbic Acid and the Adrenal Glands

The first indication that ascorbic acid had any particular connection with the activity of the adrenals came from the demonstration of morbid 

It is worth-while first to consider precisely what happens to the glands in scurvy. The following changes have been proved to occur in scorbutic guinea pigs  

Hypertrophy. McCarrison (1919) showed that the glands wei twice as much as in normal controls, though the body as a whole may be one third lighter. 

Loss of Cholesterol. Randoin and Michaux (1926) showed that cholesterol, which is normally present in high concentration in the gland, is reduced in amount. 

Loss of Ascorbic Acid. This was found by Harris and Ray (1933). 

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