Ascaris induced lung function changes

Inhibition of Ascaris induced lung function changes in reactor primates by orally administered U-42,585E. 

When lodoxamide tromethamine was administered orally to reactor Ascaris monkeys, excellent inhibition of both lung function parameters was seen Indicating a reversal of antigen challenge induced changes. Table 11 summarizes the activity of lodoxamide tromethamine and its duration of effect vAien dosed orally. This table also shows that when the optimal time (30 min.) is used to assay a dose response, inhibition can be seen as low as 5.0 mg/kg. Table 12 shows that when lodoxamide tromethamine was administered i.v. 5 min. before ascaris aerosolization (0.16 ml aerosolized in 50 respirations), protection was seen even at 0.001 mg total dose per animal (Table 13). 

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