Arylphosphines, aryl ether synthesis

Palladium-catalyzed phosphination of substituted aryl bromides, using triarylphosphines as the phosphinating agents, has been developed, as illustrated by the synthesis of (57) (Equation (18)).89 This method tolerates various functionalities, e.g., ketone, aldehyde, ester, nitrile, ether, and chloride. Under similar catalytic conditions, various P,/V-ligands, e.g., (58) (Scheme 4), were synthesized using triflate precursors instead.90,91 Arylphosphines can also be prepared by phosphination with triphenylphosphine catalyzed by palladium on charcoal.92... 

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