Arylhydrocarbon hydroxylase activities

Poland, A. and Glover, E. Chlorinated biphenyl induction of arylhydrocarbon hydroxylase activity A study of the structure-activity relationship. Mol. Pharmacol. (1977) 13 924-938. 

Ahmadizadeh M, Kuo C, Echt R, et al. 1984. Effect of polybrominated biphenyls, b-naphthoflavone and phenobarbital on arylhydrocarbon hydroxylase activities and chloroform-induced nephrotoxicity and hepatotoxicity in male C57BL/6J and DBA/2J mice. Toxicology 31 343-352. 

McCormack KM, Melrose P, Rickert DE, et al. 1979. Concomitant dietary exposure to polychlorinated biphenyls and polybrominated biphenyls Tissue distribution and arylhydrocarbon hydroxylase activity in lactating rats. Toxicol Appl Pharmacol 47 95-104. 

Evarts, R. R and Mostafa, M. H., Effects of indole and tryptophan on cytochrome P-450, dimethylnitrosamine demethylase, and arylhydrocarbon hydroxylase activities, Biochem. Pharmacol., 30[5], 517, 1981. 

Gairola C, Chow CK. 1982. Dietary selenium, hepatic arylhydrocarbon hydroxylase and mutagenic activation of benzo[a]pyrene, 2-aminoanthracene and 2-aminofluorene. Toxicol Lett 11 281-287. 

Colburn and Boutwell [206] concluded that at least there does seem to be a positive correlation of tumorigenesis with one or both of the nucleic acids DNA and RNA. Very recently, it was stated that the critical experiments have yet to be done to ascertain which (if any) of the macromolecules to which hydrocarbons (or their expoxides) bind is the primary target that triggers the carcinogenic process [139]. From quantitative structure-activity analysis, Franke [207] suggests that microsomal arylhydrocarbon benzopyrene hydroxylase may be the first step in chemical carcinogenesis of polycyclic hydrocarbons. 

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