Arylglyoxal hydrates

Singh, R.P. Shreeve, J.M. Concentration-dependent reactions of deoxofluor with arylglyoxal hydrates a new route to polyfluoro ethers. Org. Lett. 2001, 3, 2713-2715. 

Recently, Eftekhari-Sis and Vahdati-Khajeh (2013) developed a green and effective method for the preparation of 5-aryl-4-hydroxy-2-methyl-lFf-pyrrole-3-carboxylates (18) via a three-component reaction of arylglyoxal hydrates (16) with P-dicarbonyl compounds (17) in the presence of ammonium acetate using water as a solvent under ultrasonic irradiation (Scheme 8.6). The reactions proceeded rapidly and afforded the corresponding pyrroles in good to high yields in very short reaction times. 

Tu, Li, and coworkers also developed a new allylic functionalization without the use of metal catalysts [59-61]. Efficient annulation of enaminones 57 with arylglyoxal monohydrates 58 and the subsequent allylic functionalization with aliphatic carboxylic acids 38 as nucleophile reagents provided multifunctionalized indoles 98 with 75-89% yields (Scheme 12.38) [59]. To further explore the scope of this domino reaction, N-substituted 3-aminocyclohex-2-enones were employed. Interestingly, two molecules of arylglyoxal mono hydrate and N-substituted... 

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