Arylcarboxylic acid halides

A complex consisting of Cu 1.10-phenanthroline [which mediates decarboxylation of arylcarboxylic acids with formation of aryl Cu species] and Pd(acac)2 [for coupling] was made and used to catalyse the decarboxylative cross-coupling of the Cu species with aryl halides. This bimetallic system allows direct coupling of a variety of aryl, heteroaryl or vinyl carboxylic acids with aryl or heteroaryl bromides, chlorides or iodides at 160° in N methylpyrrolidine in the presence of K2CO3. [Goossen et al. JAm Chem Soc 129 4824 2007]. 

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