Arylations with the Heck-Matsuda Reaction-Recent Developments

Arylations with the Heck-Matsuda Reaction - Recent Developments 

This reaction has come much to the fore over the last few years. A number of prominent reviews have been published on the topic [19]. Given the limitations of the Heck-Mizoroki reaction (some of which are mentioned above), which are principally (i) the use of an inert atmosphere, 

In 2012, Gholinejad reported the Heck-Matsuda reaction (as well as the Suzuki-Miyaura reaction) using palladium nanoparticles [97]. The nanoparticles were supported on agarose beads, and at a loading of 2.6 pmol a variety of aryl ditizonium tetrafluoroborate salts could be coupled with 

VPC01091 - Sphingosine 1 -phosphate receptor-subtype 1 (SI PI) agonist 

A variety of stilbene products were obtained in highly satisfactory yields (66-94%) at 20 °C. The reaction supports a plethora of fimctional groups, including aryl halides. However, the reaction was not stereospecific and it gave mixtures of cis and trans isomers. This was obviously a consequence of the radical mechanism at play (a detailed mechanistic proposal was presented in this paper). 

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