Arylations of Malonates and a-Cyano Esters

In comparison to the other carbonyl compounds discussed herein, malonates usually have a relatively lower pJQ, thus allowing the use of milder bases for their arylation. Nevertheless, with these nucleophiles, strong binding to palladium (e.g. in a Tl -0,0-coordination mode) might be detrimental for reductive elimination. 

Djakovitch reported the arylation of malonates using Pd-exchanged NaY zeolites with poro-substituted aryl bromides, and compared the heterogeneous with the homogeneous reaction. Obviously, the major advantage of the heterogeneous variant is the easily removable precious metal [222]. 

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