Aryl halogenides

Die Reaktivitat der Aryl-halogenide gegeniiber den Hydriden nimmt ahnlich den Al-kyl-halogeniden in folgender Reihe ab ... 

Elements of Group IV of the Periodic System have been used in the last decade as organometallic precursors for aryl halogenide syntheses56. The mechansim of electrophilic demetalation of these precursors can be demonstrated by the simplified scheme shown in equation 14. The positive inductive effect of the alkyl substituents promotes the formation of intermediate (20) by increasing the electron density at the ipso carbon atom. 

Phosphorigsaure-diester-halogenide addieren sich ebenfalls an 1,3-Diene, wobei unter den Reaktionsbedingungen durch Abspaltung von Alkyl-(Aryl)halogenid direkt die ent-sprechenden 1 -Alkoxy(Aryloxy)-2,5-dihydro-phosphol-l - oxide erhalten wer-den404 ... 

Bis(4-methyl-2-nitrophenyl)trisulfane is formed in 84% yield on reaction of 4-chloro-3-nitrotoluene with molten sodium polysulfide. Other aryl halogenides have also been converted to trisulfanes by ionic polysulfides. ... 

The catalytic effectiveness of polymeric reagents has been demonstrated in nucleophilic substitution reactions (91), O- and N-alkylation [92] and Knoevenagel condensation [91,93]. The preparation procedure of catalyst 1 during the reaction of halogen substitution in alkyl or aryl halogenides by an anion of a potassium salt is shown in Table 7 ... 

The arylatiOTi of secondary phosphines with aryl halogenides, catalyzed by chiral complexes of platinum [116-126], mthenium [127-129], and palladium [130-139], in many cases proceeded with good enantioselectivity and can be considered as raie of methods for preparatimi of enantiomerically enriched tertiary phosphines [ 109-113]. For example, the reaction of aryl iodides with secondary arylphosphines 201, catalyzed by chiral complex Pd((R,R)-Me-Duphos) (fraiw-stilbene), furnished tertiary phosphines 206 with enantioselectivities up to 88% ee [112, 115, 118, 130]. 

The high-molecular block-copolyarylenesterketones have been S5m-thesized on the basis of 4,4 -difluorobenzophenone and number of bisphe-nols by means of reaction of nucleophylic substitution of activated aryl-halogenide in dimethylacetamide (in the presence of potassium carbonate) [394, 395]. It has been identified the cutback of molecular weight of polymer when using bisphenolate of 4,4 -(isopropylidene)bisphenol. 

Aryl derivatives of ergolines were prepared by the treatment of ergoline derivatives with the appropriate aryl halogenides under phase-transfer catalysis (Sauer et ai, 1987). 

The arylation of diphenylphosphine oxide with aryl halogenides was accomplished in the presence of NiCl2 6H20/Zn in water under mild... 

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