Artificial peptides coiled coils

Keywords Artificial peptides Coiled-coil structure Helix structure ... 

Formation of helical-like peptides stabilized due to heterocyclic bridges formed between coils by natural and artificial amino acids 99T11711. 

Fig. 3.17 Activation of gene transcription by artificial transcription factors. (Top) The artificial activator is composed of three separate functional domains. The DNA binding domain consists of the pyrrole/imidazole polyamides (shown as connected arrows). A tethered linker domain (shown as a coil) connects the DNA binding domain to the peptide activation domain (AD, shown as an oval).

The presence of foldon and Cys knot is the key to nucleate the triple helix peptide. The C-terminal domain of T4 fibritin (foldon) is obligatory for the formation of the fibritin trimer structure and can be used as an artificial trimerization domain. The C-terminal part of the T4 fibritin trimer is formed from the trimeric coiled-coil domain, which is terminated by a C-terminal trimeric [3-sheet propeller consisting of... 

---