Artificial Nucleases Copper II Complexes

The inertness of CpA in the presence of 31-Cu3 (Table 8.4) is not due to the inherently low reactivity of the substrate, nor to its insensitivity to copper(II) catalysis, as shown by the finding that CpA is cleaved by [12]aneN3-Cu and 30-Cu2 about 3 times more rapidly than UpU. Furthermore, the efficiency of 31-Cu3 in the cleavage of UpU is similar to 

28-Cu ACCAUC II CGCUGA AGGUUAA CAGGCC 1 CCGGCA ACUAUC 1 

29-CU2 ACCAUC CGCUGA AGGUUAA CAGGCC CCGGCA ACUAUC 

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