Aromatic-cation pharmacophore

The pharmacophore was first introduced by Paul Ehrlich in 1909 as a molecular framework that carries the essential features responsible for a drug s biological activity. Typical pharmacophore features include whether a molecule is hydrophobic, aromatic, a hydrogen bond acceptor or donor, and a cation or an anion and has positive or negative charges. The most common pharmacophore features have been built into various in silico modeling programs. 

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