Aromatase structure-activity relationships

Oprea, T.I. Garcia, A.E. Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors./. Comput.-Aided Mol. Des. 1996, 10, 186-200. 

Steroidal AIs have been synthesised using the structure of androstenedione as starting point for the chemical optimisation programme (Fig. 6). These inhibitors bind to the aromatase in the same manner as the substrate androstenedione. The structure-activity relationship (SAR) of the androstenedione derivatives has extensively been investigated. Although several of these... 

Oprea, T.I. and Garcia, A.E. (1996). Three-Dimensional Quantitative Structure-Activity Relationships of Steroid Aromatase Inhibitors. J.Comput.Aid.Molec.Des, 10,186-200. 

Structure-activity relationship studies have shown that the homolog of PED, 10-(2-butynyl) estr-4-ene-3,l7-dione, was a weaker suicide aromatase inhibitor compared to... 

M. Numazawa andM. Oshibe,/ Med. Chem., 37,1312 (1994). 6-Alkyl- and 6-Aiylandiost-4-ene-3,17-diones as Aromatase Inhibitors. Synthesis and Structure—Activity Relationships. 

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