Aromatase induction

Oberdorster, E. and McClellan-Green, P. (2002). Mechanisms of imposex induction in the mud snail, Ilyanassa obsoleta TBT as a neurotoxin and aromatase inhibitor. Marine Environmental Research 54, 715-718. 

For example, the induction of metabolizing enzymes by a chemical can greatly modify its PK and that of other substances, which is the subject of metabolic interactions [59], Intestinal barrier alterations due to intestinal toxicity can also affect PK [3]. Toxicity-induced retro-action mechanisms can also increase volumes of distribution The interaction of a chemical with aromatase can lead to a decrease in estradiol production and hence a decrease in FSH secretion, followed by a decrease in follicular growth and a reduction of the ovary volume [56], This should have implications for the design of in vitro assay systems. Integrated systems, such as those coupling metabolism and effect observations in human on chip micro-devices [5], offer a way to model experimentally the PK/PD continuum. 

Kagawa, N., Q. Cao, and K. Kusano (2003). Expression of human aromatase (CYP19) in Escherichia coli by N-terminal replacement and induction of cold stress response. Steroids 68, 205-209. 

Schmidt M (2013) Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor alpha. J Mol Endocrinol 2286. 51 247-260... 

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