Aromadendrane Sesquiterpenes Epiglobulol

Aromadendranes are dimethylcyclopropane azulenes collectively named after the first isolated molecule of the family (+)-aromadendrane, found as a constituent of the essential oil of Eucalyptus trees. The occurrence of these sesquiterpenes in nature is high, with the higher plants essential oils to be their major sources. Some of the biological properties that have been reported for isolated aromadendranes include antifungal, antibacterial, antifeedant, and cytotoxic activities [75]. 

In 2006, Sato and coworkers discovered an efficient cycloisomerization of polyene aldehydes leading to the construction of 5-7 condensed carbocyclic systems resem-bhng to natural aromadendrane motifs [76]. During then- 

Interestingly, the reaction cascade fails to provide cycloi-somerized products in the absence of the gem disubstitution in accordance with Trost s observations on Thorpe-Ingold effect as discussed in the previous subchapter. 

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