Armed-disarmed concept

Transfer of the Armed-Disarmed Concept to Thioglycoside Glycosylation... 

The armed-disarmed concept is tranferrable to having thioglycosides both as donors and acceptors91,92 (Scheme 9). Anomeric activation can, in favorable instances, also be used for this purpose93 (Scheme 10). 

Scheme 5.8 Armed/disarmed concept for chemoselective coupling of two w-pentenyl glycosides (NPGs). A 2-0-alkylated (armed) NPG 29 is much more readily activated than is a 2-0-acylated (disarmed) NPG 30.62...

D. Crich and M. Li, Revisiting the armed-disarmed concept The importance of anomeric configuration in the activation of S-benzoxazolyl glycosides, Org. Lett., 9 (2007) 4115 -118. 

M. N. Kamat and A. V. Demchenko, Revisiting the armed-disarmed concept rationale Chemoselective activation of the S-benzoxazolyl glycosides in oligosaccharide synthesis, Org. Lett., 7 (2005) 3215-3218. 

The third concept is programmed glycosylation based on tuning the reactivity of various glycosyl donors (73). This concept is rather similar to the armed-disarmed concept in that both make use of the distinct reactivity of differently protected glycosyl donors. However, the programmed glycosylation... 

Armed-Disarmed Concept in the Synthesis of Glycosidic Bond... 

The armed-disarmed concept, although discovered with 0-pentenyl glycosides, has been found to be applicable to many other classes of glycosides such as thioglycosides [6], selenoglycosides [39], fluorides [40], phosphoroamidates [41], substituted thioformimidates [42], glycals [21], y-benzoxazolyl (SBox), and 5-thiazolinyl (STaz) [43, 44]. 

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