Arginine finger

A further understanding of the GAP-mechanism was achieved by the arginine-finger hypothesis, where the role of a highly conserved arginine residue in Ras-GAPs of several species in completing the catalytic machinery of Ras was demonstrated by a combination of biophysical and structural (see Sect. 3.3.2) experiments [175]. 

Ahmadian MR, Stege P, Scheffzek K, Wittinghofer A. Confirmation of the arginine-finger hypothesis for the GAP-stimulated 39. GTP-hydrolysis reaction of Ras. Nat. Struct. Biol. 1997 4 686-... 

Gozani, O. and Yang, W. (2007) The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proceedings of the National Academy of Sciences of the United States of America, 104, 18993-18998. 

Frankel, A., and Clarke, S. (2000). PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain./. Biol. Chem. 275(42), 32974-32982. 

Fig. 59. Finger print of a casein hydrolysate on cellulose MN 300 plate size 20 X 20cm layer thickness 0.25 mm. 1 dimension electrophoresis with buffer of 25 ml formic acid and 78 ml acetic acid per litre 400 V and 75 min run. 2 dimension TLC with chloroform-methanol-17.5% ammonium hydroxide (41+41+18). 1 leucine + isoleucine 2 phenylalanine 3 valine 4 methionine 5 proline 6 tyrosine 7 hydroxy-proline 3 alanine 9 serine + threonine id glycine ii histidine i2 arginine + lysine 13 glutamic acid 14 aspartic acid 8 Thin-Layer Chromatography, 2nd Edition...

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