Lidocaine Argatroban

Inglis AM, Sheth SB, Hnrsting MJ, Tenero DM, Graham AM, DiCicco RA. Investigation of the interaction between argatroban and acetaminophen, lidocaine, or digoxin. Am J Health Syst Pharm 2002 59(13) 1258-66. 

The thrombin inhibitor argatroban had no effect on the pharmacokinetics of intravenous lidocaine 1.5 mg/kg for 10 minutes followed by 2 mg/kg/hour for 16 hours in 12 healthy volunteers the argatroban was given as an intravenous infusion of 2 pg/kg/minute for 16 hours (73). 

There was no pharmacokinetic interaction between argatroban and lidocaine, and no further change in coagulation parameters when both drugs were given together in a study. 

In 12 healthy subjects, lidocaine 2 mg/kg per hour was infused for 16 hours (after a loading dose of 1.5 mg/kg over 10 minutes) alone, then in combination with intravenous argatroban 1.5 micrograms/kg per minute for 16 hours. Concurrent use did not affect the pharmacokinetics of either drug. Lidocaine did not alter the effect of argatroban on aPTT. ... 

No special precautions appear likely to be necessary on concurrent use of lidocaine and argatroban. 

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