Argatroban clinical trials

Direct thrombin inhibitors such as hirudin, Hirulog, the peptide aldehyde efegatran, and peptidomimetic compound argatroban have undergone clinical trials. Their application in the prevention and treatment of deep vein thrombosis contin-... 

Table 3 Clinical trials of argatroban in acute myocardial infarction with thrombolytics ...

Ofher than argatroban, fhe only non-peptidic fhrombin inhibitors to have reached phase III clinical trials are the simple tripeptide analogue melagatran and its orally available pro-drug ximelagatran from AstraZeneca [5] (Fig. 7.15). For a recent clinical status review, see [80]. 

---