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Renal arachidonic acid metabolism

Diacerein (diacetylrhein), an anthraquinone derivative, is said to be effective in the treatment of osteoarthritis. Its active metabolite is rhein, about which there are very few clinical data. Diacerein does not affect arachidonic acid metabolism and might be better tolerated than other NSAIDs with regards to renal and gastric toxicity. Epigastric or abdominal pain and diarrhea are the most frequent adverse effects. Diarrhea occurred in 37% of patients with osteoarthritis taking diacerein (1). Acute hepatitis has been described (SEDA-22, 119), as have skin reactions. [Pg.1094]

Bennett WM. Therapeutic implications of arachidonic acid metabolism in transplant-associated acute renal failure. Ren Fail 1992 14 261-265. [Pg.439]

In contrast to the widespread mobilization of prostaglandin mechanisms within the renal vasculature, stimulation of renal arachidonic acid metabolism... [Pg.19]

The following conclusions regarding metabolism of arachidonic acid by renal cytochrome P450-linked oxygenase can be made ... [Pg.27]

Ferreri, N.R., Schwartzman, M., Ibraham, N.G., Chander, P.N. and McGiff, J.C. (1984). Arachidonic acid metabolism in a cell suspension isolated from rabbit renal outer medulla. ]. Pharmacol. Exp. Ther., 231, 441-448... [Pg.30]

ARACHIDONIC ACID METABOLISM IN RENAL DISEASE Acute renal failure... [Pg.39]

Although there is documentation of elevated renal TXA2 in human kidney disease, it will be important to explore abnormal arachidonic acid metabolism in other forms of glomerulonephritis and non-immunological forms of injury to determine how generalized the concept of enhanced TXA2 synthesis is in influencing the loss of renal function in humans. [Pg.48]

Jonas, P. E., Leahy, K. M., Deschryver-Kecskaemeti, K., Needleman, R, 1984 Cellular interactions and exaggerated arachidonic acid metabolism in rabbit renal injury. J. Leukocyte Biology 35, 55-64. [Pg.77]

See other pages where Renal arachidonic acid metabolism is mentioned: [Pg.16]    [Pg.16]    [Pg.17]    [Pg.19]    [Pg.20]    [Pg.21]    [Pg.21]    [Pg.23]    [Pg.25]    [Pg.26]    [Pg.27]    [Pg.27]    [Pg.28]    [Pg.29]    [Pg.30]    [Pg.31]    [Pg.32]    [Pg.33]    [Pg.33]    [Pg.34]    [Pg.35]    [Pg.37]    [Pg.41]    [Pg.43]    [Pg.47]    [Pg.49]    [Pg.51]    [Pg.53]    [Pg.55]    [Pg.57]    [Pg.59]    [Pg.61]    [Pg.63]    [Pg.65]    [Pg.93]   
See also in sourсe #XX -- [ Pg.16 , Pg.17 , Pg.18 , Pg.19 , Pg.20 , Pg.21 , Pg.22 , Pg.23 , Pg.24 , Pg.25 , Pg.26 , Pg.27 , Pg.28 , Pg.29 , Pg.30 , Pg.31 , Pg.32 ]



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Acids arachidonic acid

Arachidonate

Arachidonic acid

Arachidonic acid metabolism

Arachidonic acid metabolism 35 renal disease

Arachidonic acid metabolized

Arachidonic acid/arachidonate

Metabolism renal

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