Aquaporin water channels

Agre, P. (2004) Aquaporin water channels. Angewandte Chemie-Intemational Edition, 43, 4278-4290. 

Water transport across the luminal and basolateral membranes of collecting duct cells. Above, low water permeability exists in the absence of antidiuretic hormone (ADH). Below, in the presence of ADH, aquaporins are inserted into the apical membrane, greatly increasing water permeability. (AQP2, apical aquaporin water channels AQP3,4, basolateral aquaporin water channels V2, vasopressin V2 receptor.)... 

Figure 23. Aquaporin, water-channel protein, (a) End-on view of the pore from extracellular surface, (b) side-view of the pore-canal, (c) six membrane spanning helices of the aquaporin monomer. The asparagine-proline-alanine (NPA) motifs in the second and fifth loops fold in to produce the water channel.

Beitz E, Schultz JE. 1999. The mammalian aquaporin water channel family a promising new drug target. Curr Med Chem 6 457-467. 

Borgnia M, Nielsen S, Engel A, Agre P. 1999. Cellular and molecular biology of the aquaporin water channels. Annu Rev Biochem 68 425-458. 

Engel A, Fujiyoshi Y, Agre P. 2000. The importance of aquaporin water channel protein structures. EMBOJ 19 800-806. 

Ma T, Verkman AS. 1999. Aquaporin water channels in gastrointestinal physiology. J Physiol 517 317-326. 

Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science 296 525-530. 

Water Uses aquaporin water channels Absorbed osmotically along widi solutes Re-absorbed, descending loop Re-absorbed... 

Verkman AS, Mitra AK (2000) Structure and function of aquaporin water channels. Am J Physiol Renal Physiol 278 F13-F28... 

M. A. Knepper Molecular physiology of urinary concentrating mechanism Regulation of aquaporin water channels by vasopressin. American Journal of Physiology 272 (Renal Physiology 41), F3 (1997). 

Agre, R, King, L. S., Yasui, M., Guggino, W. B., Ottersen, O. R, Fujiyoshi, Y., Engel, A., and Nielsen, S. 2002. Aquaporin water channels From atomic structure to clinical medicine. /. P/iysiol.. 542 3-16. 

Agre, P., and Kozono, D. 200A. Aquaporin water channels Molecular mechanisms for human diseases. Lett. S3.S 72—78. 

C. Vasopressin, and its analog desmopressin, acts by increasing insertion of aquaporin (water channels) into the renal distal mbule membrane, permitting increased resorption of water from the urinary... 

Agre, P. (2006). The aquaporin water channels. Proceedings of the American Thoracic Society, 3 ), 5—13. 

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