Apyrimidinic acid

The 2,3-dideoxyglyc-2-enose also appears to participate in the formation of 5-oxocyclopent-l-enyl phosphate (86) found among the alkaline degradation products of apurinic and apyrimidinic acids.175 The 2,3-dideoxypent-2-enose 5-phosphate (83), formed by -elimination either from apurinic or from apyrimidinic acid, readily isomer-izes to 84, a form in which it can eliminate the 5-phosphate group or, by further rearrangement of the double bonds, cyclize to 85. The fate of 87, also an expected intermediate in the alkaline degradation of 2-deoxy-D-eryf/iro-pentose, is unknown, but it would be expected to cyclize to form 1,3-cyclopentanedione. 

AP-1 (Activator Protein) 576, 577 Apoferritin 842 Apoptosis 574, 619 Apple motif of proteins 367 Apurinic acid 250 Apyrimidinic acid 255 Aquaporins 411,412 Arabidopsis thaliana genome 12, 29 Arabinan 177 Arabinogalactan 431 L-Arabinose (Ara) 163... 

In an earlier paper, Takemura et al. (436) investigated the hydrolysis of ribo-apyrimidinic acids by commercial RNase and by isolated RNase-A and RNase-B. They observed no detectable hydrolysis with the purified enzymes and concluded that the observed action with the commercial sample resulted from a minor contaminant. This conclusion also would... 

Lindahl, T. (1979). DNA glycoslylases, endonucleases for apurinic/apyrimidinic sites and base excision repair. Proc. Nuc. Acid Res. Mol. Biol. 22 109-118. 

Drinkwater, N.R.. Miller. E.C. Miller, J.A. (1980) Estimation of apurinic/apyrimidinic sites and phosphotriesters in deoxyribonucleic acid treated with electrophilic carcinogens and mutagens. Biochemistry, 19, 5087-5092... 

Fig. 7. Effect of native DNA, denatured DNA and yeast RNA on the ultraviolet absorption spectra of distamycin (A), distamycin/4 (B) and distamycin/5 (C), in 0.01 M Tris-HC1 buffer (pH 7.0). Curve 1 is the spectrum of free antibiotics. Other curves are spectra of the antibiotics in the presence of yeast RNA (curve 2), denatured DNA (curve 3), native DNA (curve 4), apurinic acid (curve 5) and apyrimidinic DNA (curve 6) at a molar antibiotic/nuclei acid-P ratio of 0.025. Chandra et al.21 ...

Sagher, D. and Strauss, B. (1983) Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis. Uniqueness of adenine nucleotides. Biochemistry, 22,4518-4526. 

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