The data points are fit to an appropriate function (Equation 12.5). (See Figure 12.10b.) From the real data points and calculated curves, equiactive concentrations of agonist in the absence and presence of the antagonist are calculated (see Section 12.2.1). For this example, real data points for the blocked curve were used and the control concentrations calculated (control curve Emax=1.01, n = 0.9, and EC5ij = 10 pM). The equiactive concentrations are shown in Table 12.9b. [Pg.268]

The data points are fit to an appropriate function (Equation 12.5). (See Figure 12.13b.) At a response level of 0.3, an equiactive dose ratio of agonist is calculated. The respective concentrations of agonist [Pg.272]

The inhibition curves are fit to an appropriate function to allow estimation of the half maximal value for blockade (IC50). For example, the data [Pg.276]

To improve objectivity, choose auditors with appropriate functional experience but who work at different locations within the corporation. [Pg.79]

Reactive groups can be introduced into the polymer backbone by the choice of an appropriate functional monomer. Commercially available examples of such monomers ate as follows [Pg.248]

To illustrate this thermodynamic consistency test, Figs. 15, 16, and 17 show plots of the appropriate functions needed to calculate Areas I, II, and III, respectively, for the nitrogen-carbon dioxide system at 0°C the data are taken from Muirbrook (M5). Fugacity coffiecients were calculated with the modified Redlich-Kwong equation (R4). [Pg.181]

A similar intramolecular Diels-Alder strategy was employed in an efficient synthesis to an appropriately functionalized hydrindanone nucleus (212). After functionalization, Diels-Alder cyclization, and appropriate functional group manipulation, this hydrindanone was converted into ( )-cortisone. The overall process afforded ( )-cortisone in a total of 18 chemical steps in approximately 3% yield. [Pg.439]

A third variation of this strategy has been appHed to an enantioselective total synthesis of cortisone. From an appropriately functionalized, scalemic hydrindan that possessed an 11-oxo-group and a masked corticoid side-chain, (+)-cortisol was produced in an 11-step total synthesis (213). [Pg.439]

Several techniques have been applied in attaching the appropriate functionality to the polymer surface. For example, copolymeri/ation of a monomer containing functionality (alkoxyamine e.g. 358 or 359,744 ATRP initiator, e.g. 352,734 RAFT [Pg.560]

In summary, to obtain 7% from a platinum resistance thermometer, one selects the range of interest, calibrates the thermometer at the fixed points specified for those ranges, and uses the appropriate function to calculate AW(Tw) to be used in equation (A2.5). Companies are available that perform these calibrations and provide tables of W T<)0) versus 790 that can be interpolated to give 7% for a measured W T90). [Pg.624]

The /+ function is expected to reflect the initial part of a nucleophilic reaction, and the / function an electrophilic reaction, i.e. the reaction will typically occur where the / function is large. For radical reactions the appropriate function is an average of /+ and /- [Pg.352]

The two variable terms should yield very abrupt variations in the Ej(r)-modulus, since the generally large differences between the moduli of the inclusions and the matrix must be accomodated in very thin peels for the mesophases. The appropriate functions for such steep variations are power functions of radii r with large adhesion exponentsq. Then, the Ej(r)-modulus may be expressed by [Pg.161]

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