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Applying Existing ADME Models to Combinatorial Library Design

APPLYING EXISTING ADME MODELS TO COMBINATORIAL LIBRARY DESIGN [Pg.37]

FIGURE 4 Plot of the success of simultaneous optimization of pK, and predicted absorption over time for an optimization project at Pharmacopoeia Laboratories. Predicted absorption classes (ABSCLS) are 0 (good), I (moderate, 2 (poor), and 3 (bad). Caco-2 cell permeability studies confirm the general trend of absorption predictions (results not shown). [Pg.38]

IX. APPLYING EXISTING ADME MODELS TO COMBINATORIAL LIBRARY DESIGN... [Pg.37]



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ADME

ADME models

Combinatorial design

Combinatorial library

Designing Combinatorial Libraries

Designs existing

Libraries Models

Libraries, combinatorial design

Library design

Model designations

Models design

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