Application Examples for Natural Product Screening

The use of pharmacophore-based screening in the field of natural product drug discovery is one of the most recent application areas of pharmacophore models. It has been made possible by the introduction of several natural product databases for VS in 

Cruzain (cysteine protease of Tiypanosoma cruzi) Disheveled PDZ domain 

Alzheimer s disease, cancer, chronic inflammation, and type-2 diabetes Cancer 

DS CATALYST Four inhibitors showed moderate to high hypotensive activity in vivo [111] 

UNITY (GALAHAD) Three inhibitors (IC5o = 16.7, 23, and 35 pM, respectively) [117] 

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