Apparent kinetic constants inhibition studies

From the kinetic study o/lb-catalyzed hydrolysis of 4-nitrophenyl acetate inhibited by various aromatic sulfonamides, the apparent 1 1 affinity constants were determined at jH 8.4/ A comparison o/intramolecular Kntra=10 =Wor ll)/i (for la)]ond intermolecular for la with / toluenesulfonamide) contribution of p-toluenesulfonamide anion coordination to the zinc(II)-[12]aneN3 complex gives an effective mo-larity M by the intramolecular location. 

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