Apoptosis signal-regulating kinase-1 ASK

Saitoh, M. et al., Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1, Embo. J., 17, 2596,1998. 

Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., and Ichijo, H. (1998). Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17, 2596-606. 

Fig. 13.6 Control of caspases by inhibitors in oMyc-induced proliferation. Caspase inhibitors (lAPs) are inactivated by phosphorylation by ASK-1. ASK-1 is an apoptotic signal-regulated protein kinase, which binds to the CD95iyCD95 ligand-receptor complex with the help of a special linker protein. Interaction with the receptor-ligand complex activates the kinase and shuts off the caspase Inhibitors (lAPs), by phosphorylation. The caspase is activated and blocks Bcl-2, (which normally prevents apoptosis), seiKling the cell towards apoptosis.

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