Entacapone Apomorphine

Keski-Hynnilae, H., Kurkela, M., Elovaara, E., Antonio, L., Magdalou, J., Luukkanen, L., Taskinen, J., and Kostiainen, R. (2002). Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamine, and entacapone phase II metabolites in biological samples. Anal. Chem. 74, 3449-3457. 

Drugs metabolized by COMT Administer drugs known to be metabolized by COMT (ie, isoproterenol, epinephrine, norepinephrine, dopamine, dobutamine, methyidopa, apomorphine, isoetherine, bitolterol) with caution in patients receiving entacapone regardless of the route of administration (including inhalation), as their interaction may result in increased heart rates, arrhythmias, and excessive changes in blood pressure. 

Amantadine (Symmetrel) Entacapone (Comtan) Apomorphine (Apokyn) Pramipexole (Mirapex)... 

Entacapone had no effect on the pharmacokinetics or efficacy of apomorphine in a single-dose study. Similarly, tolcapone had no relevant effect on single-dose apomorphine. 

The evidence from these single-dose studies suggest that there is no pharmacokinetic interaction between entacapone or tolcapone and apomorphine, and that the drugs can be used together without alteration of the apomorphine dose. However, fiirther data are required from longer-term concurrent use to confirm this. Until more is known, increased monitoring during concurrent use of COMT inhibitors and apomorphine may be prudent, as is recommended by the manufacturers. ... 

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