Apomorphine COMT inhibitors

In vitro and animal data suggested that the enzyme eatechol-O-methyl transferase (COMT) is involved in the metabolism of apomorphine and that COMT inhibitors might increase apomorphine bioavailability. However, the single dose studies above suggest that this metabolie pathway for apomorphine may not be important in humans. 

The evidence from these single-dose studies suggest that there is no pharmacokinetic interaction between entacapone or tolcapone and apomorphine, and that the drugs can be used together without alteration of the apomorphine dose. However, fiirther data are required from longer-term concurrent use to confirm this. Until more is known, increased monitoring during concurrent use of COMT inhibitors and apomorphine may be prudent, as is recommended by the manufacturers. ... 

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