Apolar cyclodienes

Since elimination of these apolar cyclodienes does take place in fish, we examined the nature of radioactivity in both fish and water. 

Photolysis of 2-bromo-4,4-dimethyl-2-cyclohexenone only affords reduction, even in a nucleophilic medium343,344. Apparently, this substrate is structurally not suitable to form a vinyl cation. Formation of vinyl radical-derived products is also the main process for all vinylic halides, if their irradiation is performed in an apolar medium. Such photochemical reductive dehalogenation and especially dechlorination reactions have been extensively studied in the past, not in the least because of their importance as abiotic transformation of persistent polychlorinated environmental pollutants. Examples are the cyclodiene insecticides aldrin and dieldrin, which contain a vicinal dichloroethene chromophore. In recent... 

Their presence in these products is not surprising since as a group the cyclodienes are apolar, lipophilic compounds. Acceptable daily intake for cyclodienes has been established by the World Health Organization and tolerance limits in meats and poultry set by the US-EPA. Development of an immunoassay for these compounds would greatly facilitate improved monitoring for cyciodienes in foods and environmental samples. We have isolated a monoclonal antibody, LLNL-Hept-2. that detects cyclodiene insecticides and have used this antibody to develop an immunoassay that is able to detect heptachlor (and related chlorinated cyciodienes) in meat, flsh and dairy products. 

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See also in sourсe #XX -- [ ]

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