Aplysina insularis

Ciminiello P, Fattorusso E, Magno S, Pansini M (1996) Chemistry of Verongida Sponges VI. Comparison of the Secondary Metabolic Composition of Aplysina insularis and Aplysina fulva. Biochem Syst Ecol 24 105... 

Fendert T, Wray V, van Soest RWM, Proksch P (1999) Bromoisoxazoline Alkaloids from the Caribbean Sponge Aplysina insularis. Z Naturforsch 54c 246... 

Purealidins J (116) and K (117) were isolated from the Okinawan sponge Psammaplysilla purea by Kobayashi et al. (7P). The absolute stereochemistry of the spirocyclohexadienylisoxazoline was determined by the positive Cotton effects at 248 and 184 nm in the CD spectra. Purealidin K was subjected to ozonolysis, followed by oxidation with H2O2, and subsequently acid hydrolysis. Chiral HPLC analysis of the hydrolysate revealed D- and L-2,4-diaminobutyric acids in the ratio of 1 1, suggesting that C-12 of purealidin K is racemic. A similar alkaloid, 14-oxo-aerophobin-2 (118), was identified from the Caribbean sponge Aplysina insularis 88). The stereochemistry of C-13 was not determined. 

Compagnone RS, Avila R, Suarez AI, Abrams OV, Rangel HR, Arvelo F, Pina IC, Merentes E (1999) ll-Deoxyfistularin-3, a New Cytotoxic Metabolite from the Caribbean Sponge Aplysina fistularis insularis. J Nat Prod 62 1443... 

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