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Antiulcer H2-receptor histamine

Another particularly impressive example of ring bio-isosterism is found in the development of the antiulcer H2-receptor histamine antagonists in which the initial imidazole ring was changed to various other equivalents ... [Pg.194]

The antiulcer drug famotidine 115 exerts its activity by blocking the histamine H2 receptor in a similar manner to cimetidine. Famoti-... [Pg.274]

Katsura Y, Nishino S, Inoue Y et al (1992) Studies on antiulcer drugs. HI. Synthesis and antiulcer activities of imidazo[l, 2-a]pyridinylethyl-benzoxazoles and related compounds. A novel class of histamine H2-receptor antagonists. Chem Pharm Bull 40 1424—1438... [Pg.92]

Show histamine H2 - receptor antagonism and antiulcer activity. 238... [Pg.271]

Fig. 1. Schematic diagram showing the different mechanisms of action proposed for the antiulcer action of flavonoids. 1. Blockade of add secretion by decreasing histamine production or inhibiting the proton pump. 2. Bactericidal effect on H. pylori. 3. Antioxidative activity by scavenging free radicals and preventing ROM formation. 4. Potentiation of the mucosal protective factors. PAF platelet activating factor ROM reactive oxygen metabolites H2 histamine receptor 2 M muscarinic receptor G gastrin receptor. Fig. 1. Schematic diagram showing the different mechanisms of action proposed for the antiulcer action of flavonoids. 1. Blockade of add secretion by decreasing histamine production or inhibiting the proton pump. 2. Bactericidal effect on H. pylori. 3. Antioxidative activity by scavenging free radicals and preventing ROM formation. 4. Potentiation of the mucosal protective factors. PAF platelet activating factor ROM reactive oxygen metabolites H2 histamine receptor 2 M muscarinic receptor G gastrin receptor.
See other pages where Antiulcer H2-receptor histamine is mentioned: [Pg.303]    [Pg.303]    [Pg.303]    [Pg.303]    [Pg.288]    [Pg.72]    [Pg.241]    [Pg.39]    [Pg.234]    [Pg.587]    [Pg.253]    [Pg.680]    [Pg.539]    [Pg.539]    [Pg.1133]    [Pg.25]    [Pg.1045]    [Pg.318]    [Pg.283]   


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Antiulcer

Antiulcerative

Antiulcers

H2 receptor

Histamine H2 receptors

Receptors histaminic

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