Antitumor constituents

Structure of Rabdophyllin G, an Antitumor Constituent of Rabdosia macrophylla. Yaoxue Tongbao 17, 174 (1982) [Chem. Abstr. 97, 115212r (1982)]. 

Hua Hsueh Hsueh Pao 1976 Studies on the antitumor constituents of Cephalotaxus hainanensis. Hua Hsueh Hsueh Pao 34 283-293... 

Wang XF, Chen JY, Wei RF, Jiang DQ 1981 Studies on the antitumor constituents of Maytenus confertiflora Luo et Chen (Celastraceae). II. Isolation and characterization of maytansine and maytanprine from the stems. Yao Hsueh Hsueh Pao 16 628-630... 

Because only very limited quantities of Gulf of California L. iso-dictyalis were available from recollections made at various times from 1976-1978 and because of the substantial challenges involved in isolating what appeared to be a series of complex antitumor constituents present in only trace amounts, all efforts to solve this problem until 1982 were unrewarding. During a 1976 expedition we explored some 1500 miles of... 

Recently Uemura et al. 202a) isolated a new type macrolide with antitumor activity, worhalichondrin A (335), from Halichondria okadai. 335 was the major compound in a series of halichondrins, the most potent antitumor constituent being halichondrin B, the structure of which is not yet published. 

TABLE 4 Cytotoxi c and Antitumor Constituents from Different Lichen Species ... 

Shen, Y.-C., Lo, K.-L., Kuo, Y.-H., and Chakraborlhy, R. (2002) Polycyclic quinones and hydroquinones, antitumor constituents from Taiwanese marine sponge Xestospongia sp. Chin. Pharm. J., 54, 207-213. 

In the course of detailed studies on the chemical constituents of rutaceous plants, genus Xanthoxylum, known to contain the antitumor benzophen-anthridine alkaloids, Ishii et al. (167-173) have isolated four seco amide alkaloids arnottianamide (206), iwamide (207), integriamide (208), and isoarnottianamide (209). Sharma et al. (174) have also found arnottianamide (206) in Toddia Asiatica. 

The reader is referred to other reviews for detailed discussions of the electronic states and luminescence of nucleic acids and their constituents/0 fluorescence correlation spectroscopy/2) spectroscopy of dye/DNA complexes/0 and ethidium fluorescence assays/4,0 A brief review of early work on DNA dynamics as well as a review of tRNA kinetics and dynamics have also appeared. The diverse and voluminous literature on the use of fluorescence techniques to assay the binding of proteins and antitumor drugs to nucleic acids and on the use of fluorescent DNA/dye complexes in cytometry and cytochemistry lies entirely outside the scope of this chapter. 

Wall, M. E., H. Taylor, L. Ambrosio, and K. Davis. Plant Antitumor agents III a convenient separation of tannins from other plant constituents. J Pharm... 

The dried roots of Asian ginseng are used for medicinal purposes and its main constituents are triterpene saponins known as ginsenosides or panaxosides. The pharmacologic actions of ginseng include immunomodulatory, anti-inflammatory, antitumor, smooth muscle relaxation, stimulant, and hypoglycemic effects (36). 

Chromomycin A> is the principal constituent of chromomycin,2 4 a complex mixture of antitumor antibiotics produced by Streptomyces griseus 7. Mild hydrolysis by acid2 -2 9 of chromomycin A produces four 2,6-dideoxy-... 

Crocus sativus L., commonly known as saffron, is used in folk medicine as an antispasmodic, eupeptic, gingival sedative, anticatarrhal, nerve sedative, carminative, diaphoretic, expectorant, stimulant, stomachic, aphrodisiac, and emmenagogue. Furthermore, modem pharmacological studies have demonstrated that saffron extract or its active constituents have antitumor effects, radical scavenger properties, and hypolipemic effects (see Rios et al., 1996). 

Computational Studies on Platinum Antitumor Complexes and Their Adducts with Nucleic-Acid Constituents... 

The aim of the present contribution is to critically review computational work related to platinum antitumor drugs, published prior to 1998. After a section devoted to molecular-orbital calculations on platinum antitumor complexes and related compounds, we address force-field calculations on platinum adducts with DNA constituents that have been used (mainly in combination with NMR spectroscopy) to evaluate the structure of the adduct. A brief outlook concludes this chapter. 

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