Oximes antitumor activity

Soga, S., L. M. Neckers, T. W. Schulte, Y. Shiotsu, K. Akasaka, H. Narumi, T. Agatsuma, Y. Ikuina, C. Murakata, T. Tamaoki, and S. Akinaga. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. Cancer Res. 59 2931-8.1999. 

The antitumor activities of indole and isatin oximes and of furan oximes were studied by several investigators. Furan oximes were found to inhibit DNA, RNA and protein synthesis in lipoid leukemia cells. Derivatives of quinoline oximes were also shown to possess antitumor activity , and glucosinolates, 15, were suggested as cancer-preventive agents . ... 

Agatsuma, T. et al. 2002. Halohydrin and oxime derivatives of radicicol synthesis and antitumor activities. Bioorg. Med. Chem. 10, 3445-3454. 

---