Antitumor activity gallium salts

Hart MM, Adamson RH. 1971. Antitumor activity and toxicity of salts of inorganic group Ilia metals Aluminum, gallium, indium, and thallium. Proc Natl Acad Sci U S A 68 1623-1626. 

Hart MM, Smith CE, Yancey ST and Adamson RH (1971) Toxicity and antitumor activity of gallium nitrate and periodically related metal salts. J Natl Cancer Inst 47 1121-1127. 

The antitumor activity of gallium(III) salts (especially nitrate) has been evaluated in phase I and phase II trials [15-18]. The phase II trials have shown that gallium nitrate exhibits antitumor activity in patients with refractory lymphomas [19]. 

Autoradiographic studies of gallium-67 salts in rodent tissue show more than 70% of the 67ca activity was localized in the cytoplasm. High concentrations of Ga were observed in the epithelium of renal convoluted tubules.Four Group III-A elements (aluminum, gallium, indium, and thallium) had some antitumor activity but only Ga+3 and, to a lesser extent, In" inhibited tumor growth when the tumor was Innoculated by a... 

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