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Antitubulin effect

Alcohol 10, obtained from 7 on reduction with sodium borohydride, and acetate 11, prepared from 10 by acetylation (72), are obviously mixtures of isomers, and as such they are of little value for evaluating their antitubulin effects. Testing of an optically pure isomer of 11, as shown below, which is isosteric to colchicine, would be of interest. [Pg.130]

Anti-Inflammatory Activity and Antitubulin Effects of Selected Colchicinoids"... [Pg.164]

Methoxy indole-containing combretastatin derivatives, (I), and prodrugs, (II), prepared by Pinney (2) were found effective as antimitotic and antitubulin polymerization agents and used in the selective destruction of tumor cell vasculature. [Pg.545]

See other pages where Antitubulin effect is mentioned: [Pg.160]    [Pg.164]    [Pg.276]    [Pg.160]    [Pg.164]    [Pg.276]    [Pg.164]    [Pg.91]    [Pg.111]    [Pg.118]    [Pg.247]    [Pg.101]    [Pg.111]    [Pg.118]    [Pg.39]    [Pg.44]    [Pg.696]    [Pg.385]    [Pg.1150]   


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Antitubulin

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