Antituberculosis drugs second line

Capreomycin and viomycin show activity against M. tuberculosis and may be regarded as being second-line antituberculosis drugs. 

Antituberculosis drugs are classified as first-line and second-line. 

In cases of renal insufficiency, streptomycin and ethambutol or second-line antituberculosis drugs with renal toxicity should be immediately withdrawn. 

Multidrug-resistant tuberculosis generally results from inadequate therapy or lack of compliance with therapy. A strain of mycobacteria is called resistant when it is insensitive to one of the first-line drugs. It is called multiresistant when it is insensitive to both isoniazid and rifampicin. In this case other antituberculosis drugs may also be ineffective (35). In practice, at least two second-line antituberculosis drugs, selected on the basis of individual drug susceptibility, are given in combination with a fluoroquinolone (36). 

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