Antithrombotic agents, injectable

The fatal complications caused by toxin-LR in mice are unusual. Toxin-LR is a potent thrombogenic agent. Generally, such agents bring about symptoms of illness within a few minutes of injection of a lethal dose. However, toxin-LR produces no overt signs of illness until about one-half hour has elapsed. Moreover, pretreatment of mice with known antithrombotic agents does not affect the lethality of the toxin. 

LMW heparin, enoxaparin, for preventing VTE after major orthopedic surgery (30). The results from a meta-analysis show thiat fondaparinux (10) is associated with an overall risk reduction versus enoxaparin for the prevention of venous thromboembolism. Of aiU the LMW heparins, enoxaparin is widely regarded as the treatment standard for VTE prophylaxis. Fondaparinux (10) is an injectable solution for the prevention of DVT and is the only antithrombotic agent approved in the United States for hip fracture surgery. 

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