Antisickling agents

WiREKO, F.C. Abraham, D.J. X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin. Proc. Natl. Acad. Sci. U. S. 

Kennedy, P.E., Williams, F.L., Abraham, D.J. Design, synthesis, and testing of potential antisickling agents. 3. 

The second antisickling agent proposed by Abraham et al. to advance to clinical trials was the food additive vanillin (compound la)... 

Zinc is known to compete with cadmium, lead, copper, iron, and calcium for similar binding sites (109). In the future, a potential use of zinc may be to alleviate toxic effects of cadmium and lead in human subjects. Use of zinc as an antisickling agent is an example of its antagonistic effect on calcium, which is known to produce irreversible sickle cells by its action on red-cell membrane. 

Cho, Y.W. et al. (1996) Clinical Pharmacology for Pediatricians. II. Antisickling agents, with special reference to new vasoerythroactive drugs. /. C/in. Pharmacol.. 22,1-13. 

Klotz, I. M., Haney, D. N., King, L. C., Rational Approaches to Chemotherapy Antisickling Agents, Science 213 724-731, 1981. 

Rifai, N. Sakamoto, M. Law, T. Platt, O. Mikati, M. Armsby, C.C. Brugnara, C. HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin.Chem., 1995, 41, 387-391... 

Lce, C. K. (1976). Meihyli ocyanaie as an antisickling agent and its reaction with hemoglobin S. 7. Biot. Chem. 251,6226-6231. 

Isolation and characterization of an antisickling agent from Fagara zanthoxyloides root. Lloydia 38 169-171. 

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