Oligomers antisense

Sazani P., Gemignani F., Kang S.H., Maier M.A., Manoharan M., Persmark M., Bortner D., Kole R. Systemically delivered antisense oligomers upregulate... 

It was also found that SMC proliferation could be inhibited by antisense oligomers via nonantisense mechanisms (39). In this case, the presence of four contiguous guanosine residues (G-4 tract) within the oligonucleotide sequence caused a sequence-specific, but not antisense-dependent, antiproliferative effect. 

Shi Y Fad A, Galleon A, et al. Transcatheter delivery of c-myc antisense oligomers reduced neointimal formation in a porcine model of coronary artery balloon injury. Circulation I 994 90 944-951. 

Summerton J, Stein D, Huang B, Matthews R Weller D, Partridge M, Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems, Antisense Nucleic Acid Drug Dev 1997 7 63-70,... 

Summerton, J. (1999) Morpholino antisense oligomers the case for an RNase FI-independent structural type. Biochim Biophys Acta. 1489, 141-158. 

Branda RF, Moore AL, Hong R, Mccormack JJ, Zon G, Cunningham-Rundles C. B-cell proliferation and differentiation in common variable immunodeficiency patients produced by an antisense oligomer to the rev gene of hiv-1. Clin Immunol Immunopathol 1996 79(2) 115—21. 

To aid hepato-cellular uptake of antisense ODNs, the phosphoramidites of cholic and taurocholic acids were prepared and added to the 5 -end of antisense oligomers." The oligonucleotides were further modified by the inclusion of phosphorothioate and benzylphosphonate internucleotide linkages. The bile acid conjugated oligomers exhibited enhanced lipophilicity as determined by HPLC, and when incorporated into duplexes no destabilisation was observed. An antisense phosphorothioate ODN targeted to the HIV-1 gag-mKNA was... 

Figure 2. RNA processing and translation intracellular action of antisense oligomers.

Figure 4L Dose-dependent toxicity of phosphorothioate antisense oligomers (Inhibitors of PKC-a (ISIS 3521/CGP 64126A) and C-ra/kinasc (ISIS 5132/CGP 69846A)). Modified from [445],...

Amantana A, Iversen P L (2005). Pharmacokinetics and bio distribution of phospho-rodiamidate morpholino antisense oligomers. Curr. Opin. Pharmacol. 5 550-555. 

Arora V, Devi G R, Iversen P L (2004). Neutrally charged phosphorodiamidate morpholino antisense oligomers uptake, efficacy and pharmacokinetics. Curr. Pharm. Biotechnol. 5 431-439. 

Sazani, P. et al., Systemically delivered antisense oligomers upregulate gene expression in mouse tissues, Nat. Biotechnol, 20,1228,2002. 

Duff RJ, Deamond SF, Roby C, Zhou Y, Tso POP (2000) Intrabody tissue-specific delivery of antisense conjugates in animals ligand-linker-antisense oligomer conjugates. Methods Enzymol 313 297-321... 

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