Antineoplastics Quinolones

Uncertain. The interaction seems to result from a reduction in the absorption of the quinolones by the small intestine, possibly related to the damaging effect cytotoxic antineoplastics have on the rapidly dividing cells of the intestinal mucosa. 

Direct information is limited, but these reports are consistent with the way cytotoxic antineoplastics can reduce the absorption of some other drugs. The authors of both reports suggest that these changes are probably clinically unimportant, because the serum levels of achieved are likely to be sufficient to treat most infections. If the suggested mechanism of interaction is correct, no interaction should occur if quinolones are given parenterally. Nothing appears to be documented about any of the other quinolones. 

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