Antineoplastic agent dolastatin

The pentapeptide dolastatin 10 (198) was isolated from D. auricularia and the structure was proposed on the basis of spectral studies [195], Dolastatin 10 (198) is a very potent antineoplastic agent. The absolute configuration proposed from spectral analysis was confirmed by synthesis [196] and dolastatin 10 (198) has subsequently been synthesised by several other research groups [197-199],... 

Pettit GR, Xu J-P, Doubek DL, Chapuis J-C, Schmidt JM (2004) Antineoplastic Agents 510. Isolation and Structure of Dolastatin 19 from the Gulf of California Sea Hare Dolabella auricularia. J Nat Prod 67 1252... 

Poncet, J., The dolastatins, a family of promising antineoplastic agents, Curr. Pharm. Des., 5, 139,... 

Pettit GR, Singh SB, Hogan F, Lloyd-Williams P, Herald DL, Burkett DD, Clewlow PJ. Antineoplastic agents. Part 189. The absolute configuration and synthesis of namral -dolastatin 10. J. Am. Chem. Soc. 1989 111 5463-5465. 

Pettit, G.R., Kamano, Y, Herald, C.L., Fujii, Y, Kizu, H., Boyd, M.R., Boettner, F.E., Doubek, D.L., and Schmidt, J.M. (1993a) Antineoplastic agents. Part 247. The dolastatins. Part 18. Isolation and structure of dolastatins 10-15 from the marine mollusc Dolabella auricularia. Tetrahedron, 49, 9151-9170. 

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