Dopamine agonists Antihypertensives

Antihypertensives, diuretics, antipsychotics, tricyclic antidepressants, levodopa, dopamine agonists, a-blockers Corticosteroids NSAIDs, anticoagulants -Blockers (non-selective)... 

Haeusler G, Lues I, Minck KO, Schelling P, Seyfried CA (1992) Pharmacological basis for antihypertensive therapy with a novel dopamine agonist. Eur Heart J 13 Suppl D 129-35 Hakansson K, Pozzi L, Usiello A, Haycock J, Borrelli E, Fisone G (2004) Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol. Eur J Neurosci 20 1108-12... 

May decrease the effects of levodopa, dopamine agonists > May increase the effects of antihypertensive drugs except for... 

Dopamine inhibits prolactin synthesis. Drugs that inhibit dopamine synthesis or activity (e.g. antihypertensives, antidepressants, estrogen, phenothiazines, opiates), are the most common cause of hyperprolactinemia. Prolactin-secreting pituitary tumors sometimes are treated with bromocriptine, a dopamine agonist. 

All dopamine agonists can cause hypotensive reactions during the first few days of treatment. It is not clear whether this patient was extremely sensitive to the pergolide or whether what occurred was due to an interaction. However, it is not unreasonable to assume that the hypotensive effects of dopamine agonists and antihypertensives might be additive. 

Postural hypotension on starting dopamine agonists is a well recognised adverse effect, but this appears to be the only report that this might be of more concern in patients taking antihypertensives. The manufacturers of pergolide recommend caution when it is given with antihypertensives be-... 

Bromocriptine (Parl el) [Antiparkinsonian Agent/Dopamine Receptor Agonist] Uses Parkin on Dz, hyperprolactinemia, acromegaly, pituitary tumors Action Direct-acting on the striatal dopamine receptors X prolactin secretion Dose Initial, 1.25 mg PO bid titrate to effect, w/ food Caution [B, ] Contra Severe ischemic heart Dz or PVD Disp Tabs, caps SE X BP, Raynaud phenomenon (vasospastic disorder resulting in discoloration of the fmgers/toes), dizziness, N, hallucinations Interactions T Effects W/ erythromycin, fluvoxamine, nefazodone, sympathomimetics, antihypertensives X effects W/ phenothiazines, antipsychotics EMS Monitor BP may cause intolerance to EtOH OD May cause NA, severe hypotension give IV fluids symptomatic and supportive... 

Several of the compound types in this chapter have useful biological activities. This is not unexpected since many of those compounds which are effective in the modification of responses to bioamines are themselves organic bases. Quinelorane (114) which is a potent dopamine (D2) agonist has been patented as an antihypertensive and antiparkinsonism agent <85USP4501890>. 

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