Antihistamines pharmacological profile

Despite their common ability to enhance serotonergic function in vivo, the SSRIs differ both in terms of their pharmacological profiles and their pharmacokinetics. Thus in addition to their direct inhibitory action on the serotonin transporter, they also affect other neurotransmitter systems which may have some clinical relevance. Citalopram has a modest antihistamine action which might account for its slightly sedative action. Sertraline has a... 

The drug possesses less toxicity in comparison to tripeleimamine and thonzylamine. It exhibits both antihistaminic and anaesthetic pharmacological profile. 

In the treatment of children and adolescents with anxiety disorders clinicians have a wide variety of pharmacologic options beyond the antidepressants (Shader and Greenblatt, 1995 Lydiard et ah, 1996 Riddle et ah, 1999). The benzodiazepines (BZs), with their favorable safety profile and quick onset of action, are attractive alternatives for the treatment of acute anxiety. While the clinical effectiveness of buspirone has not been proven in children, buspirone is used alone or in combination with other drugs in the treatment of anxiety disorders. The antihistamines are often used to treat insomnia and may reduce acute mild agitation. Zolpidem (Ambien) is occasionally used for its sedative properties. This chapter reviews the structure, proposed mechanisms of action, pharmacodynamic principles, and pharmacokinetic principles of these drugs. 

FIGURE 11 — 15. Haloperidol pharmacological icon. Haloperidol is different from many of the other conventional antipsychotic drugs in that it is more potent it also lacks potent antimuscarinic and antihistaminic binding activities. Otherwise, its clinical profile is highly conventional. 

This profile of pharmacological activity confirms that the pyrimido-[4,5-b]quinoline ester XXXV inhibits the release of the mediators of anaphylaxis, and is neither a bronchodilator nor an antihistamine. 

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