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Antihistamines delirium

The classic anticholinergic (technically, "antimuscarinic") syndrome is remembered as "red as a beet" (skin flushed), "hot as a hare" (hyperthermia), "dry as a bone" (dry mucous membranes, no sweating), "blind as a bat" (blurred vision, cycloplegia), and "mad as a hatter" (confusion, delirium). Patients usually have sinus tachycardia, and the pupils are usually dilated (see Chapter 8). Agitated delirium or coma may be present. Muscle twitching is common, but seizures are unusual unless the patient has ingested an antihistamine or a tricyclic antidepressant. Urinary retention is common, especially in older men. [Pg.1256]

In large doses, atropine induces stimulation of the CNS, which in humans is characterized by overactive coordinated movements, hallucinations, and delirium. After the stimulation has lasted for some time, depression sets in and may proceed to complete paralysis of the CNS, which is fatal through cessation of respiration. In infants, particularly those ingesting antihistamines, paradoxical excitement may occur subsequently followed by a more characteristic CNS depression. CNS manifestations may resemble acute psychosis characterized by incoherence, confusion, hallucinations, delusions, paranoia, and abnormal motor behavior. [Pg.147]

Antimuscarinic dmgs (atropine, some antidepressarts and antihistaminics, jimsonweed, etc) Delirium, hallucinations, seizures, coma, tachycardia, hypertension, hyperthermia, mydriasis, decreased bowel sounds, urinary retention Control hyperthenaia physostigmine may be helpful, but not for tricyclic overdose... [Pg.519]

Anticholinergic (antimuscarinic) syndrome. Tachycardia with mild hypertension is common. The pupils are widely dilated. The skin is flushed, hot, and dry. Peristalsis is decreased, and urinary retention is common. Patients may have myoclonic jerking or choreoathetoid movements. Agitated delirium is common, and hyperthermia may occur. (Examples atropine, scopolamine, benztropine, antihistamines, and antidepressants all of these dmgs are primarily antimuscarinic.)... [Pg.30]

B. Specific drugs and antidotes. There is no specific antidote for antihistamine overdose. As for anticholinergic poisoning (see p 84), physostigmine has been used for treatment of severe delirium or tachycardia. However, because antihistamine overdoses carry a greater risk for seizures, physostigmine is not routinely recommended. Sodium bicarbonate (see p 419), 1-2 mEq/kg IV, may be useful for myocardial depression and QRS intenral prolongation after a massive diphenhydramine overdose. [Pg.98]

Unfortunately, antihistamine overdose is common. The list of symptoms include agitation, blurred vision, coma, confusion, convulsions, delirium, diarrhea, drowsiness, dry mouth, flushing, inability to urinate, incoherence, lack of sweat, fever, nausea, rapid heart rate, stomach pain, and unsteadiness. The patient may be treated with activated charcoal, oxygen, IV fluids, and gastric lavage. If the patient survives the first 24 hours after an antihistamine overdose, fatalities are rare (NIH, 2010). [Pg.219]


See other pages where Antihistamines delirium is mentioned: [Pg.51]    [Pg.183]    [Pg.636]    [Pg.239]    [Pg.292]    [Pg.301]    [Pg.135]    [Pg.427]    [Pg.55]    [Pg.147]    [Pg.1291]    [Pg.294]   
See also in sourсe #XX -- [ Pg.654 ]




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