Antiepileptic drugs idiopathic epilepsy

Primary epilepsy When no specific anatomic cause for the seizure, such as trauma or neoplasm, is evident the syndrome is called idiopathic or primary epilepsy. These seizures may be produced by an inherited abnormality in the central nervous system (CNS). Patients are treated chronically with antiepileptic drugs, often for life. 

Thomas P, Valton L, Genton P. Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy. Brain 2006 129 1281-1292. 

Teratogenicity In an analysis of the medical records of 284 valproate-exposed pregnancies in the North American Antiepileptic Drug Pregnancy Registry 30 (11.0%) were associated with malformations [388 ]. There were 15/126 (12%) malformations in patients with idiopathic generalized epilepsy, 4/28 (14%) in patients with partial epilepsy, 9/105 (9%) in those... 

Mandelbaum DE, Burack GD, Bhise W. Impact of antiepileptic drugs on cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy. Epilepsy Behav 2009 16(2) 341-4. 

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