Antidepressant drugs surface activity

This oral CrDDS is prepared by granulating Valium, an antidepression drug, with hydrocolloids (20-75 wt%) and pharmaceutical excipients. The granules are then compressed to form an oral tablet. After oral intake, the hydrocolloids absorb the gastric fluid and are activated to form a colloid gel matrix surroimding the tablet surface (Fig. 22). The release of Valium molecules... 

The isocitrate dehydrogenase activity in human serum has been determined by kinetic assay at 37°C, with isocitrate and NADP as substrates. The rate of formation of NADPH was amperometrically monitored and the selectivity was improved by covering the active surface of the electrode with a poly(o-phe-nylenediamine) film. The electroimmobilization of the enzyme monoamine oxidase into a polypyrrole film around a platinum electrode has been used to determine the antidepressant drug fluoxetine in pharmaceutical preparations. 

Many drugs are surface active, e.g. chlorpromazine, diphenylmethane derivatives (such as diphenhydramine) and tricyclic antidepressants (such as amitriptyline) [14]. As an illustration is the structure of chlorpromazine (13.3). 

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