Antidepressant drugs dosage

Chinese depressed patients appeared to require lower dosages, with consequently lower plasma concentrations of sertraline compared to Caucasian patients to achieve clinical efficacy (Ng et al, 2006). Again, this finding has supported the fact that Asian patients, especially Chinese, need lower doses of antidepressant drugs than their Western counterparts. 

Ayd, F. J. (1974). Once-a-day dosage of tricyclic antidepressant drug therapy A survey. Diseases of the Nervous System, 35, 475-480. 

Depression has been attributed to amiodarone in a 65-year-old woman who was taking amiodarone (dosage not stated) (15). Because the mode of presentation was atypical in onset, course, duration, and its response to antidepressant drugs, amiodarone was withdrawn, and she improved rapidly. There was no evidence of thyroid disease. 

Bupropion (brand name Wellbutrin) An antidepressant drug known to induce seizures and therefore administered with specific recommendations on dosage ranges. It should not be administered concurrently with MAOIs. 

Taha, E. A. Soliman, S. M. Abdellatef, H. E. Ayad, M. M. Colorimetric methods for the determination of some tricychc antidepressant drugs in their pure and dosage forms original paper. Mikrochim. Acta 2002,140, 175-182. 

MISCELLANEOUS ANTIDEPRESSANTS. An uncommon but potentially serious adverse reaction of trazodone is priapism (a persistent erection of die penis). If not treated within a few hours, priapism can result in impotence The nurse instructs the patient to report any prolonged or inappropriate penile erection. Use of the drug is discontinued immediately and the primary care provider notified. Injection of a-adrenergic stimulants (eg, norepinephrine) may be helpful in treating priapism. In some cases, surgical intervention may be required. Venlafaxine may cause an increase in die blood pressure. A sustained increase in die blood pressure may indicate that die dosage of venlafaxine needs to be decreased. 

Explains the reason for drug therapy, including the type of antidepressant prescribed, drug name, dosage, and frequency of administration. 

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