Anticoagulant action of heparin and heparinoids

Anticoagulant Action of Heparin and Heparinoids The basic facts about the anticoagulant action of heparin are that (f) 1 to 10 pg is effective in delaying the clotting of 1 ml. of blood or plasma  

In defining anticoagulants above, it was emphasized that heparin in concentrations of 0 1 mg/ml. and over, shows general inhibitory effects and this has led to much confusion in the literature. The important problem is the nature of the action of the heparin-cofactor complex which provides the unique high activity of heparin. In analysing the inhibitory effect of heparin in plasma systems, the essential constituent is the cofactor and its concentration is an unknown limiting variable in many investigations . 

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